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This Concept Map, created with IHMC CmapTools, has information related to: LAB 21 - USING ANTIMICROBIAL CHEMOTHERAPY TO CONTROL MICROORGANISMS, Using antimicrobial chemotherapy to control microorganisms mechanisms of microbial resistance to chemotherapeutic agents Producing enzymes which detoxify or inactivate the antibiotic, e.g., penicillinase and other beta-lactamases., Using antimicrobial chemotherapy to control microorganisms definitions antimicrobial chemotherapeutic chemicals, automated tests description Measures the inhibitory effect of the antimicrobial agents in a liquid medium by using light scattering to determine growth of the test organism., Using antimicrobial chemotherapy to control microorganisms mechanisms of microbial resistance to chemotherapeutic agents Preventing transport of the antimicrobial agent into the bacterium, eg., producing an altered cytoplasmic membrane or outer membrane., Using antimicrobial chemotherapy to control microorganisms definitions antibiotics, Using antimicrobial chemotherapy to control microorganisms definitions static, Using antimicrobial chemotherapy to control microorganisms definitions antimicrobial chemotherapy, Alter the bacterial cytoplasmic membrane causing leakage of cellular needs. examples Polymyxin B, amphotericin B, nystatin, imidazoles, Using antimicrobial chemotherapy to control microorganisms definitions broad-spectrum agent, Alter 30S or 50S bacterial ribosomes blocking translation. examples Aminoglycosides, tetracyclines, lincomycin, clindamycin, macrolides, oxazolidinones, streptogramins, Using antimicrobial chemotherapy to control microorganisms mechanisms of microbial resistance to chemotherapeutic agents Developing an alternate metabolic pathway to by-pass the metabolic step being blocked by the antimicrobial agent, e.g., overcoming drugs that resemble substrates and tie-up bacterial enzymes., Using antimicrobial chemotherapy to control microorganisms modes of action Prevent the synthesis of bacterial mRNA off of DNA blocking transcription., antibiotics definition Substances produced as metabolic products of one microorganism which inhibit or kill other microorganisms. (Most antibiotics today are semisynthetic.), Using antimicrobial chemotherapy to control microorganisms mechanisms of microbial resistance to chemotherapeutic agents Increasing the production of a certain bacterial enzyme, e.g., overcoming drugs that resemble substrates and tie-up bacterial enzymes., Using antimicrobial chemotherapy to control microorganisms modes of action Interfering with bacterial DNA synthesis., Prevent the synthesis of bacterial mRNA off of DNA blocking transcription. examples Rifampins, Using antimicrobial chemotherapy to control microorganisms modes of action Alter 30S or 50S bacterial ribosomes blocking translation., narrow-spectrum agent definition Effective against just gram-positive bacteria, just gram negative bacteria, or only a few species., Using antimicrobial chemotherapy to control microorganisms definitions cidal, Interfering with bacterial DNA synthesis. examples Fluoroquinolones, sulfonamides and trimethoprim, metronidazole